Telmisartan Mitigates TNF-α-Induced Type II Collagen Reduction by Upregulating SOX-9

[Image: see text] The proinflammatory cytokine tumor necrosis factor-α (TNF-α)-induced degradation of extracellular matrix (ECM), such as type II collagen in chondrocytes, plays an important role in the development of osteoarthritis (OA). Telmisartan, an angiotensin II (Ang-II) receptor blocker, is...

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Pubblicato in:ACS Omega
Autori principali: Zhang, Xiuying, Dong, Yanfeng, Dong, Hanyu, Cui, Yanhui, Du, Qing, Wang, Xiaoli, Li, Lanlan, Zhang, Hongju
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154015/
https://ncbi.nlm.nih.gov/pubmed/34056329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.1c01170
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