Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

[Image: see text] Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followe...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Ahlqvist, Grace P., McGeough, Catherine P., Senanayake, Chris, Armstrong, Joseph D., Yadaw, Ajay, Roy, Sarabindu, Ahmad, Saeed, Snead, David R., Jamison, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153789/
https://ncbi.nlm.nih.gov/pubmed/34056192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.1c00772
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