Prolonged Codelivery of Hemagglutinin and a TLR7/8 Agonist in a Supramolecular Polymer–Nanoparticle Hydrogel Enhances Potency and Breadth of Influenza Vaccination

[Image: see text] The sustained release of vaccine cargo has been shown to improve humoral immune responses to challenging pathogens such as influenza. Extended codelivery of antigen and adjuvant prolongs germinal center reactions, thus improving antibody affinity maturation and the ability to neutr...

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Publicat a:ACS Biomater Sci Eng
Autors principals: Roth, Gillie A., Saouaf, Olivia M., Smith, Anton A. A., Gale, Emily C., Hernández, Marcela Alcántara, Idoyaga, Juliana, Appel, Eric A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153386/
https://ncbi.nlm.nih.gov/pubmed/33404236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.0c01496
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