Prolonged Codelivery of Hemagglutinin and a TLR7/8 Agonist in a Supramolecular Polymer–Nanoparticle Hydrogel Enhances Potency and Breadth of Influenza Vaccination

[Image: see text] The sustained release of vaccine cargo has been shown to improve humoral immune responses to challenging pathogens such as influenza. Extended codelivery of antigen and adjuvant prolongs germinal center reactions, thus improving antibody affinity maturation and the ability to neutr...

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Bibliografiska uppgifter
I publikationen:ACS Biomater Sci Eng
Huvudupphovsmän: Roth, Gillie A., Saouaf, Olivia M., Smith, Anton A. A., Gale, Emily C., Hernández, Marcela Alcántara, Idoyaga, Juliana, Appel, Eric A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2021
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153386/
https://ncbi.nlm.nih.gov/pubmed/33404236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.0c01496
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