Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

Phenotypic screening identified a benzothiophene compound with activity against Leishmania donovani, the causative agent of visceral leishmaniasis. Using multiple orthogonal approaches, oxidosqualene cyclase (OSC), a key enzyme of sterol biosynthesis, was identified as the target of this racemic com...

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Gepubliceerd in:Cell Chem Biol
Hoofdauteurs: Paradela, Luciana S., Wall, Richard J., Carvalho, Sandra, Chemi, Giulia, Corpas-Lopez, Victoriano, Moynihan, Eoin, Bello, Davide, Patterson, Stephen, Güther, Maria Lucia S., Fairlamb, Alan H., Ferguson, Michael A.J., Zuccotto, Fabio, Martin, Julio, Gilbert, Ian H., Wyllie, Susan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153249/
https://ncbi.nlm.nih.gov/pubmed/33691122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.02.008
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