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Preclinical Characterization of the Selective JAK1 Inhibitor LW402 for Treatment of Rheumatoid Arthritis

BACKGROUND: Research on JAK family members as therapeutic targets for autoimmune diseases has brought tofacitinib and baricitinib into clinical for the treatment of rheumatoid arthritis and other autoimmune diseases. Despite the potent efficacy of these first-generation JAK inhibitors, their broad-s...

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Bibliographische Detailangaben
Veröffentlicht in:J Inflamm Res
Hauptverfasser: Zhang, Ning, Zhang, Changqing, Zeng, Zhihong, Zhang, Jiyong, Du, Shengnan, Bao, Chunde, Wang, Zhe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8153205/
https://ncbi.nlm.nih.gov/pubmed/34054304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S301076
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