New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells

Transmembrane channel-like protein isoform 1 (TMC1) is a major component of the mechano-electrical transducer (MET) channel in cochlear hair cells and is subject to numerous mutations causing deafness. We report a new dominant human deafness mutation, TMC1 p.T422K, and have characterized the homolog...

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Xehetasun bibliografikoak
Argitaratua izan da:J Neurosci
Egile Nagusiak: Beurg, Maryline, Schimmenti, Lisa A., Koleilat, Alaa, Amr, Sami S., Oza, Andrea, Barlow, Amanda J., Ballesteros, Angela, Fettiplace, Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2021
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152607/
https://ncbi.nlm.nih.gov/pubmed/33824189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2537-20.2021
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