Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206

Polymyxins are an important class of antibiotics for the treatment of bacterial infections due to multi-drug resistant Gram-negative pathogens. However, their clinical utility is limited by nephrotoxicity. Here we report a series of promising next-generation polymyxin nonapeptides identified based o...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Brown, Pamela, Abbott, Elizabeth, Abdulle, Omar, Boakes, Steven, Coleman, Scott, Divall, Naomi, Duperchy, Esther, Moss, Stephen, Rivers, Dean, Simonovic, Mona, Singh, Jaspal, Stanway, Steven, Wilson, Antoinette, Dawson, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8152168/
https://ncbi.nlm.nih.gov/pubmed/31525992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00217
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