Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5(NULL)-A20

We previously developed a refined, tumor-selective adenovirus, Ad5(NULL)-A20, harboring tropism ablating mutations in each major capsid protein, to ablate all native means of infection. We incorporated a 20-mer peptide (A20) in the fiber knob for selective infection via αvβ6 integrin, a marker of ag...

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Publicado en:Viruses
Main Authors: Davies, James A., Marlow, Gareth, Uusi-Kerttula, Hanni K., Seaton, Gillian, Piggott, Luke, Badder, Luned M., Clarkson, Richard W. E., Chester, John D., Parker, Alan L.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151668/
https://ncbi.nlm.nih.gov/pubmed/34066836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13050864
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