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Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model

SIMPLE SUMMARY: Metastatic melanoma patients may present with multiple, simultaneous metastases that are genetically different. This intertumoral heterogeneity can cause these tumors to respond differently to the same systemic therapy. Progression of any one tumor, even when others regress, eventual...

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Bibliografski detalji
Izdano u:Cancers (Basel)
Glavni autori: Qin, Shuyang S., Han, Booyeon J., Williams, Alyssa, Jackson, Katherine M., Jewell, Rachel, Chacon, Alexander C., Lord, Edith M., Linehan, David C., Kim, Minsoo, Reuben, Alexandre, Gerber, Scott A., Prieto, Peter A.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151632/
https://ncbi.nlm.nih.gov/pubmed/34064795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102293
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