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In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents

Olorofim is a novel antifungal drug that belongs to the orotomide drug class which inhibits fungal dihydroorotate dehydrogenase (DHODH), thus halting pyrimidine biosynthesis and ultimately DNA synthesis, cell growth and division. It is being developed at a time when many invasive fungal infections e...

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Détails bibliographiques
Publié dans:J Fungi (Basel)
Auteurs principaux: Georgacopoulos, Ourania, Nunnally, Natalie S., Ransom, Eric M., Law, Derek, Birch, Mike, Lockhart, Shawn R., Berkow, Elizabeth L.
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150786/
https://ncbi.nlm.nih.gov/pubmed/34065811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jof7050378
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