Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial

IMPORTANCE: Fluid therapy is an important component of care for patients with traumatic brain injury, but whether it modulates clinical outcomes remains unclear. OBJECTIVE: To determine whether continuous infusion of hypertonic saline solution improves neurological outcome at 6 months in patients wi...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Roquilly, Antoine, Moyer, Jean Denis, Huet, Olivier, Lasocki, Sigismond, Cohen, Benjamin, Dahyot-Fizelier, Claire, Chalard, Kevin, Seguin, Philippe, Jeantrelle, Caroline, Vermeersch, Véronique, Gaillard, Thomas, Cinotti, Raphael, Demeure dit Latte, Dominique, Mahe, Pierre Joachim, Vourc’h, Mickael, Martin, Florian Pierre, Chopin, Alice, Lerebourg, Celine, Flet, Laurent, Chiffoleau, Anne, Feuillet, Fanny, Asehnoune, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2021
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150692/
https://ncbi.nlm.nih.gov/pubmed/34032829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2021.5561
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