Empirical Evaluation of the Use of Computational HLA Binding as an Early Filter to the Mass Spectrometry-Based Epitope Discovery Workflow

SIMPLE SUMMARY: Many different human leukocyte antigen (HLA)-types exist across the population that each binds a specific motif of amino acids. HLA-peptide complexes are the driving force behind recognition of cancers and infected cells by cytotoxic T cells. HLA-immunopeptidomics aims to identify pe...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Bouzid, Rachid, de Beijer, Monique T. A., Luijten, Robbie J., Bezstarosti, Karel, Kessler, Amy L., Bruno, Marco J., Peppelenbosch, Maikel P., Demmers, Jeroen A. A., Buschow, Sonja I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150281/
https://ncbi.nlm.nih.gov/pubmed/34065814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102307
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