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Annotating high-impact 5′untranslated region variants with the UTRannotator

SUMMARY: Current tools to annotate the predicted effect of genetic variants are heavily biased towards protein-coding sequence. Variants outside of these regions may have a large impact on protein expression and/or structure and can lead to disease, but this effect can be challenging to predict. Con...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioinformatics
Main Authors: Zhang, Xiaolei, Wakeling, Matthew, Ware, James, Whiffin, Nicola
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150139/
https://ncbi.nlm.nih.gov/pubmed/32926138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btaa783
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