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Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer
Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression, albeit with often uncharacterized roles in altering cell signaling states. Here, we integrate genomic and proteomic data for 5,598 tumor samples to identify CNVs leading to aberrant signal transductio...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8149807/ https://ncbi.nlm.nih.gov/pubmed/34010657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109155 |
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