A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion

Human organogenesis remains relatively unexplored for ethical and practical reasons. Here, we report the establishment of a single-cell transcriptome atlas of the human fetal pancreas between 7 and 10 post-conceptional weeks of development. To interrogate cell–cell interactions, we describe InterCom...

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Publicat a:Nat Commun
Autors principals: Gonçalves, Carla A., Larsen, Michael, Jung, Sascha, Stratmann, Johannes, Nakamura, Akiko, Leuschner, Marit, Hersemann, Lena, Keshara, Rashmiparvathi, Perlman, Signe, Lundvall, Lene, Thuesen, Lea Langhoff, Hare, Kristine Juul, Amit, Ido, Jørgensen, Anne, Kim, Yung Hae, del Sol, Antonio, Grapin-Botton, Anne
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149728/
https://ncbi.nlm.nih.gov/pubmed/34035279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23295-6
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