Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

The analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for testing. We propose a statistical method to detect and localize rare and common risk variants in whole-genome sequencing studies based on a r...

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Bibliographic Details
Published in:Nat Commun
Main Authors: He, Zihuai, Liu, Linxi, Wang, Chen, Le Guen, Yann, Lee, Justin, Gogarten, Stephanie, Lu, Fred, Montgomery, Stephen, Tang, Hua, Silverman, Edwin K., Cho, Michael H., Greicius, Michael, Ionita-Laza, Iuliana
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149672/
https://ncbi.nlm.nih.gov/pubmed/34035245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22889-4
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