Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response

The current pathological and molecular classification of pancreatic ductal adenocarcinoma (PDAC) provides limited guidance for treatment options, especially for immunotherapy. Cancer-associated fibroblasts (CAFs) are major players of desmoplastic stroma in PDAC, modulating tumor progression and ther...

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Veröffentlicht in:Cell Discov
Hauptverfasser: Wang, Yu, Liang, Yiyi, Xu, Haiyan, Zhang, Xiao, Mao, Tiebo, Cui, Jiujie, Yao, Jiayu, Wang, Yongchao, Jiao, Feng, Xiao, Xiuying, Hu, Jiong, Xia, Qing, Zhang, Xiaofei, Wang, Xujun, Sun, Yongwei, Fu, Deliang, Shen, Lei, Xu, Xiaojiang, Xue, Jing, Wang, Liwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Singapore 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149399/
https://ncbi.nlm.nih.gov/pubmed/34035226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-021-00271-4
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