Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period

Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR) signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the neonatal period, we investigated the influence of rapamycin, an mTOR Complex 1 (mTORC1) inhibitor, on deficits in spatial memory...

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Pubblicato in:Biomolecules
Autori principali: Lopatynska-Mazurek, Malgorzata, Antolak, Anna, Grochecki, Pawel, Gibula-Tarlowska, Ewa, Bodzon-Kulakowska, Anna, Listos, Joanna, Kedzierska, Ewa, Suder, Piotr, Silberring, Jerzy, Kotlinska, Jolanta H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147055/
https://ncbi.nlm.nih.gov/pubmed/33924998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11050650
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