Rapamycin Improves Spatial Learning Deficits, Vulnerability to Alcohol Addiction and Altered Expression of the GluN2B Subunit of the NMDA Receptor in Adult Rats Exposed to Ethanol during the Neonatal Period

Ethanol exposure during pregnancy alters the mammalian target of rapamycin (mTOR) signaling pathway in the fetal brain. Hence, in adult rats exposed to ethanol during the neonatal period, we investigated the influence of rapamycin, an mTOR Complex 1 (mTORC1) inhibitor, on deficits in spatial memory...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Lopatynska-Mazurek, Malgorzata, Antolak, Anna, Grochecki, Pawel, Gibula-Tarlowska, Ewa, Bodzon-Kulakowska, Anna, Listos, Joanna, Kedzierska, Ewa, Suder, Piotr, Silberring, Jerzy, Kotlinska, Jolanta H.
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147055/
https://ncbi.nlm.nih.gov/pubmed/33924998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11050650
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