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Targeting Cutaneous T-Cell Lymphoma Cells by Ingenol Mebutate (PEP005) Correlates with PKCδ Activation, ROS Induction as Well as Downregulation of XIAP and c-FLIP

New therapeutic strategies are needed for cutaneous T-cell lymphoma (CTCL), and the plant extract ingenol mebutate (PEP005) may be considered. PEP005 has been approved for actinic keratosis, and proapoptotic activities were described in different cancer cells. Here, we aimed to investigate its effic...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Sumarni, Uly, Reidel, Ulrich, Eberle, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146015/
https://ncbi.nlm.nih.gov/pubmed/33922439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10050987
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