Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide

Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compounds, such as methylglyoxal, are generated from sugars both endo...

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Publicat a:Nutrients
Autors principals: Tan, Sih Min, Lindblom, Runa S. J., Ziemann, Mark, Laskowski, Adrienne, Granata, Cesare, Snelson, Matthew, Thallas-Bonke, Vicki, El-Osta, Assam, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Cooper, Mark E., Murphy, Michael P., Coughlan, Melinda T.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8145135/
https://ncbi.nlm.nih.gov/pubmed/33922959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu13051457
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