Histamine can be Formed and Degraded in the Human and Mouse Heart

Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in humans via H(2)-histamine receptors. In transgenic mi...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Neumann, Joachim, Grobe, Juliane M., Weisgut, Jacqueline, Schwelberger, Hubert G., Fogel, Wieslawa Agnieszka, Marušáková, Margaréta, Wache, Hartmut, Bähre, Heike, Buchwalow, Igor B., Dhein, Stefan, Hofmann, Britt, Kirchhefer, Uwe, Gergs, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144513/
https://ncbi.nlm.nih.gov/pubmed/34045955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.582916
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