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Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration–Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation

A computational workflow which integrates physiologically based kinetic (PBK) modeling, global sensitivity analysis (GSA), approximate Bayesian computation (ABC), and Markov Chain Monte Carlo (MCMC) simulation was developed to facilitate quantitative in vitro to in vivo extrapolation (QIVIVE). The w...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Loizou, George, McNally, Kevin, Dorne, Jean-Lou C. M., Hogg, Alex
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144460/
https://ncbi.nlm.nih.gov/pubmed/34045957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.630457
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