PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure

The active zone of a presynaptic nerve terminal defines sites for neurotransmitter release. Its protein machinery may be organized through liquid–liquid phase separation, a mechanism for the formation of membrane-less subcellular compartments. Here, we show that the active zone protein Liprin-α3 rap...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Emperador-Melero, Javier, Wong, Man Yan, Wang, Shan Shan H., de Nola, Giovanni, Nyitrai, Hajnalka, Kirchhausen, Tom, Kaeser, Pascal S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144191/
https://ncbi.nlm.nih.gov/pubmed/34031393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23116-w
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