Neurotrophic effects of Botulinum neurotoxin type A in hippocampal neurons involve activation of Rac1 by the non-catalytic heavy chain (HC(C)/A)

Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in preclinical models. Here we report that the non...

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Detalhes bibliográficos
Publicado no:IBRO Neurosci Rep
Main Authors: Solabre Valois, Luis, Shi, Vanilla (Hua), Bishop, Paul, Zhu, Bangfu, Nakamura, Yasuko, Wilkinson, Kevin A., Henley, Jeremy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143998/
https://ncbi.nlm.nih.gov/pubmed/34041508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibneur.2021.04.002
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