Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

Virus infection, such as hepatitis B virus (HBV), occasionally causes endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is counteractive machinery to ER stress, and the failure of UPR to cope with ER stress results in cell death. Mechanisms that regulate the balance between ER s...

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Pubblicato in:PLoS Pathog
Autori principali: Baudi, Ian, Isogawa, Masanori, Moalli, Federica, Onishi, Masaya, Kawashima, Keigo, Ishida, Yuji, Tateno, Chise, Sato, Yusuke, Harashima, Hideyoshi, Ito, Hiroyasu, Ishikawa, Tetsuya, Wakita, Takaji, Iannacone, Matteo, Tanaka, Yasuhito
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8143404/
https://ncbi.nlm.nih.gov/pubmed/33979382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009228
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