Krüppel like factor 10 prevents intervertebral disc degeneration via TGF-β signaling pathway both in vitro and in vivo

BACKGROUND: Krüppel like factor 10 (KLF10), which is also known as TGF-β Inducible Early Gene-1 (TIEG1), plays a crucial role in regulating cell proliferation, cell apoptosis and inflammatory reaction in human carcinoma cells. Moreover, KLF10 knockout in mice leads to severe defects associated with...

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Veröffentlicht in:J Orthop Translat
Hauptverfasser: Wu, Tongde, Li, Xinhua, Jia, Xuebing, Zhu, Ziqi, Lu, Jiawei, Feng, Hang, Shen, Beiduo, Guo, Kai, Li, Yuzhi, Wang, Qiang, Gao, Zhiqiang, Yu, Bin, Ba, Zhaoyu, Huang, Yufeng, Wu, Desheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Chinese Speaking Orthopaedic Society 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141503/
https://ncbi.nlm.nih.gov/pubmed/34094855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jot.2021.04.003
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