FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

Abstract Intervertebral disc degeneration (IVDD), a leading cause of chronic low back pain, arises from nucleus pulposus (NP) cell dysfunction due to oxidative stress‐induced mitophagy impairment and ferroptosis, though regulatory mechanisms remain unclear. F‐box only protein 2 (FBXO2), a Kruppel‐li...

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Bibliografiset tiedot

Päätekijät:	Tongde Wu, Yanjin Wang, Beiduo Shen, Kai Guo, Ziqi Zhu, Yongzhou Liang, Jianhua Zeng, Desheng Wu
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2025-09-01
Sarja:	Advanced Science
Aiheet:	FBXO2 ferroptosis intervertebral disc degeneration LCN2 mitophagy
Linkit:	https://doi.org/10.1002/advs.202506150
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