Genome-Wide Epigenetic Landscape of Lung Adenocarcinoma Links HOXB9 DNA Methylation to Intrinsic EGFR-TKI Resistance and Heterogeneous Responses

PURPOSE: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) show efficacy in treating patients with lung adenocarcinoma with EGFR-activating mutations. However, a significant subset of targeted patients fail to respond. Unlike acquired resistance (AR), intrinsic resistance (IR...

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Bibliographic Details
Published in:JCO Precis Oncol
Main Authors: Su, Sheng-Fang, Liu, Chia-Hsin, Cheng, Chiou-Ling, Ho, Chao-Chi, Yang, Tsung-Ying, Chen, Kun-Chieh, Hsu, Kuo-Hsuan, Tseng, Jeng-Sen, Chen, Huei-Wen, Chang, Gee-Chen, Yu, Sung-Liang, Li, Ker-Chau
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2021
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ORIGINAL REPORTS
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8140798/
https://ncbi.nlm.nih.gov/pubmed/34036228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00151
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