Development of a multi-parameter prognostic score to guide systemic therapy in early-stage HER2-positive breast cancer: a retrospective study with an external evaluation

BACKGROUND: In early-stage HER2-positive (HER2+) breast cancer, escalation or de-escalation of systemic therapy is a controversial topic. As an aid to treatment decisions, we present a prognostic assay that integrates multiple data types for predicting survival outcome in newly diagnosed HER2+ breas...

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Pubblicato in:Lancet Oncol
Autori principali: Prat, Aleix, Guarneri, Valentina, Paré, Laia, Griguolo, Gaia, Pascual, Tomás, Dieci, Maria Vittoria, Chic, Núria, González-Farré, Blanca, Frassoldati, Antonio, Sanfeliu, Esther, Cejalvo, Juan Miguel, Muñoz, Montserrat, Bisagni, Giancarlo, Brasó-Maristany, Fara, Urso, Loredana, Vidal, Maria, Brandes, Alba Ariela, Adamo, Barbara, Musolino, Antonino, Miglietta, Federica, Conte, Benedetta, Oliveira, Mafalda, Saura, Cristina, Pernas, Sònia, Alarcón, Jesús, Llombart-Cussac, Antonio, Cortés, Javier, Manso, Luis, López, Rafael, Ciruelos, Eva, Schettini, Francesco, Villagrasa, Patricia, Carey, Lisa A., Perou, Charles M., Piacentini, Federico, D’Amico, Roberto, Tagliafico, Enrico, Parker, Joel. S., Conte, Pierfranco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8140650/
https://ncbi.nlm.nih.gov/pubmed/33152285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(20)30450-2
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