A novel RANKL‐targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species

BACKGROUND AND PURPOSE: Osteoporosis is characterized by excessive bone resorption due to enhanced osteoclast activation. Stimulation of nuclear factor of activated T cells 1 (NFATc1) and accumulation of reactive oxygen species (ROS) are important mechanisms underlying osteoclastogenesis. Robinin (R...

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Dettagli Bibliografici
Pubblicato in:Clin Transl Med
Autori principali: Hong, Guoju, Chen, Zhenqiu, Han, Xiaorui, Zhou, Lin, Pang, Fengxiang, Wu, Rishana, Shen, Yingshan, He, Xiaoming, Hong, Zhinan, Li, Ziqi, He, Wei, Wei, Qiushi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8140192/
https://ncbi.nlm.nih.gov/pubmed/34047464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.392
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