CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

Tubulointerstitial inflammation plays a key role in the pathogenesis of diabetic nephropathy (DN). Interleukin-1β (IL-1β) is the key proinflammatory cytokine associated with tubulointerstitial inflammation. The NLRP3 inflammasome regulates IL-1β activation and secretion. Reactive oxygen species (ROS...

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Vydáno v:Cell Death Dis
Hlavní autoři: Hou, Yanjuan, Wang, Qian, Han, Baosheng, Chen, Yiliang, Qiao, Xi, Wang, Lihua
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8140121/
https://ncbi.nlm.nih.gov/pubmed/34021126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03813-6
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