Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

BACKGROUND: Trimethylamine‐N‐oxide (TMAO) has recently been identified as a novel and independent risk factor for promoting atherosclerosis through inducing vascular inflammation. However, the exact mechanism is currently unclear. Studies have established a central role of nucleotide‐binding oligome...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Chen, Ming‐liang, Zhu, Xiao‐hui, Ran, Li, Lang, He‐dong, Yi, Long, Mi, Man‐tian
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5634285/
https://ncbi.nlm.nih.gov/pubmed/28871042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006347
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