Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs, but its role at the synapse is poorly understood. Using super-resolution imaging we determined that the localization of...

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Pubblicato in:Nat Commun
Autori principali: Sahadevan, Sonu, Hembach, Katharina M., Tantardini, Elena, Pérez-Berlanga, Manuela, Hruska-Plochan, Marian, Megat, Salim, Weber, Julien, Schwarz, Petra, Dupuis, Luc, Robinson, Mark D., De Rossi, Pierre, Polymenidou, Magdalini
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8140117/
https://ncbi.nlm.nih.gov/pubmed/34021139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23188-8
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