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Chromatin-associated MRN complex protects highly transcribing genes from genomic instability
MRN-MDC1 plays a central role in the DNA damage response (DDR) and repair. Using proteomics of isolated chromatin fragments, we identified DDR factors, such as MDC1, among those highly associating with a genomic locus upon transcriptional activation. Purification of MDC1 in the absence of exogenous...
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| Vydáno v: | Sci Adv |
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| Hlavní autoři: | , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Association for the Advancement of Science
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8139584/ https://ncbi.nlm.nih.gov/pubmed/34020942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb2947 |
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