Chromatin-associated MRN complex protects highly transcribing genes from genomic instability

MRN-MDC1 plays a central role in the DNA damage response (DDR) and repair. Using proteomics of isolated chromatin fragments, we identified DDR factors, such as MDC1, among those highly associating with a genomic locus upon transcriptional activation. Purification of MDC1 in the absence of exogenous...

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Vydáno v:Sci Adv
Hlavní autoři: Salifou, Kader, Burnard, Callum, Basavarajaiah, Poornima, Grasso, Giuseppa, Helsmoortel, Marion, Mac, Victor, Depierre, David, Franckhauser, Céline, Beyne, Emmanuelle, Contreras, Xavier, Dejardin, Jérôme, Rouquier, Sylvie, Cuvier, Olivier, Kiernan, Rosemary
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139584/
https://ncbi.nlm.nih.gov/pubmed/34020942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb2947
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