NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis

NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for diabetes. While the mechanism of NMDA receptor inhibition in beta cells is rather well understood at the molecular...

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Udgivet i:PLoS Comput Biol
Main Authors: Šterk, Marko, Križančić Bombek, Lidija, Skelin Klemen, Maša, Slak Rupnik, Marjan, Marhl, Marko, Stožer, Andraž, Gosak, Marko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139480/
https://ncbi.nlm.nih.gov/pubmed/33974632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1009002
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