Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs

BACKGROUND: Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lactic acid, an abundant end-product of NP glycolysis, has long been viewed as a ha...

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Bibliografske podrobnosti
izdano v:Arthritis Res Ther
Main Authors: Wang, Dong, Hartman, Robert, Han, Chao, Zhou, Chao-ming, Couch, Brandon, Malkamaki, Matias, Roginskaya, Vera, Van Houten, Bennett, Mullett, Steven J., Wendell, Stacy G., Jurczak, Michael J., Kang, James, Lee, Joon, Sowa, Gwendolyn, Vo, Nam
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139157/
https://ncbi.nlm.nih.gov/pubmed/34020698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02501-2
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