In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration

Fluorescent staining of newly transcribed RNA via metabolic labelling with 5-ethynyluridine (EU) and click chemistry enables visualisation of changes in transcription, such as in conditions of cellular stress. Here, we tested whether EU labelling can be used to examine transcription in vivo in mouse...

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Bibliografische gegevens
Gepubliceerd in:Acta Neuropathol Commun
Hoofdauteurs: van’t Sant, Lisanne J., White, Joshua J., Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Jaarsma, Dick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2021
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139001/
https://ncbi.nlm.nih.gov/pubmed/34020718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01200-y
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