An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry

Prucalopride was widely used for chronic constipation, which is difficult to be adequately relieved by laxatives in adult patients in clinic. Due to the difficulty in metabolite identification, metabolic process of prucalopride had not been investigated in vivo. In this study, an efficient strategy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Zuo, Lihua, Liu, Liwei, Yang, Yantao, Yang, Jie, Chen, Min, Zhang, Huafeng, Kang, Jian, Zhang, Xiaojian, Wang, Jiabo, Sun, Zhi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2021
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138455/
https://ncbi.nlm.nih.gov/pubmed/34025397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.610226
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