The Common Germline TP53-R337H Mutation is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

The TP53-R337H founder mutation exists at a high frequency throughout southern Brazil and represents one of the most common germline TP53 mutations reported to date. It was identified in pediatric adrenocortical tumors in families with a low incidence of cancer. The R337H mutation has since been fou...

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Publicado no:Cancer Res
Main Authors: Jeffers, John R., Pinto, Emilia M., Rehg, Jerold E., Clay, Michael R., Wang, Jinling, Neale, Geoffrey, Heath, Richard J., Lozano, Guillermina, Lalli, Enzo, Figueiredo, Bonald C., Pappo, Alberto S., Rodriguez-Galindo, Carlos, Chen, Wenan, Pounds, Stanley, Ribeiro, Raul C., Zambetti, Gerard P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137600/
https://ncbi.nlm.nih.gov/pubmed/33637564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1750
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