Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer

There is a strong correlation between myeloid derived suppressor cells (MDSCs) and resistance to immune checkpoint blockade (ICB), but the detailed mechanisms underlying this correlation are largely unknown. Using single-cell RNA-seq analysis in a bilateral tumor model, we found that immunosuppressi...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Xin, Gang, Chen, Yao, Topchyan, Paytsar, Kasmani, Moujtaba Y., Burns, Robert, Volberding, Peter J, Wu, Xiaopeng, Cohn, Alexandra, Chen, Yiliang, Lin, Chien-Wei, Ho, Ping-Chih, Silverstein, Roy, Dwinell, Michael B., Cui, Weiguo
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137571/
https://ncbi.nlm.nih.gov/pubmed/33579728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0433
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