Immunosuppressive Myeloid Cells Induce Nitric Oxide-dependent DNA Damage and p53 Pathway Activation in CD8+ T cells

Tumor-infiltrating myeloid-derived suppressor cells (MDSCs) are associated with poor survival outcomes in many human cancers. MDSCs inhibit T cell-mediated tumor immunity in part because they strongly inhibit T-cell function. However, whether MDSCs inhibit early or later steps of T-cell activation i...

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Publicat a:Cancer Immunol Res
Autors principals: Cartwright, Adam N. R., Suo, Shengbao, Badrinath, Soumya, Kumar, Sushil, Melms, Johannes, Luoma, Adrienne, Bagati, Archis, Saadatpour, Assieh, Izar, Benjamin, Yuan, Guo-Cheng, Wucherpfennig, Kai W.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137551/
https://ncbi.nlm.nih.gov/pubmed/33514509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0085
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