Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

BACKGROUND: Pituitary dysfunction is a life-threatening immune-related adverse event (irAE) induced by immune checkpoint inhibitors (ICIs). To date, it is not possible to identify patients who may develop pituitary irAEs prior to ICI treatment. The aim of this study was to characterize the predispos...

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Publicado en:J Immunother Cancer
Main Authors: Kobayashi, Tomoko, Iwama, Shintaro, Sugiyama, Daisuke, Yasuda, Yoshinori, Okuji, Takayuki, Ito, Masaaki, Ito, Sachiko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Nishikawa, Hiroyoshi, Arima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2021
Assuntos:
Immunotherapy Biomarkers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137231/
https://ncbi.nlm.nih.gov/pubmed/34011534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002493
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