Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors

BACKGROUND: Pituitary dysfunction is a life-threatening immune-related adverse event (irAE) induced by immune checkpoint inhibitors (ICIs). To date, it is not possible to identify patients who may develop pituitary irAEs prior to ICI treatment. The aim of this study was to characterize the predispos...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Kobayashi, Tomoko, Iwama, Shintaro, Sugiyama, Daisuke, Yasuda, Yoshinori, Okuji, Takayuki, Ito, Masaaki, Ito, Sachiko, Sugiyama, Mariko, Onoue, Takeshi, Takagi, Hiroshi, Hagiwara, Daisuke, Ito, Yoshihiro, Suga, Hidetaka, Banno, Ryoichi, Nishikawa, Hiroyoshi, Arima, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Immunotherapy Biomarkers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137231/
https://ncbi.nlm.nih.gov/pubmed/34011534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002493
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