Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice

The immunoglobulin heavy chain binding protein (BiP), also referred to as 78-kDa glucose-regulated protein (GRP78), is a pivotal endoplasmic reticulum (ER) chaperone which modulates the unfolded protein response under ER stress. Our previous studies showed that BiP is expressed in arginine vasopress...

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Udgivet i:Sci Rep
Main Authors: Kawaguchi, Yohei, Hagiwara, Daisuke, Miyata, Takashi, Hodai, Yuichi, Kurimoto, Junki, Takagi, Hiroshi, Suga, Hidetaka, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Ito, Yoshihiro, Iwama, Shintaro, Banno, Ryoichi, Grinevich, Valery, Arima, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7661499/
https://ncbi.nlm.nih.gov/pubmed/33184425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76839-z
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