Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Misfolded or unfolded proteins in the ER are said to be degraded only after translocation or isolation from the ER. Here, we describe a mechanism by which mutant proteins are degraded within the ER. Aggregates of mutant arginine vasopressin (AVP) precursor were confined to ER-associated compartments...

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Bibliografski detalji
Izdano u:iScience
Glavni autori: Miyata, Takashi, Hagiwara, Daisuke, Hodai, Yuichi, Miwata, Tsutomu, Kawaguchi, Yohei, Kurimoto, Junki, Ozaki, Hajime, Mitsumoto, Kazuki, Takagi, Hiroshi, Suga, Hidetaka, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Ito, Yoshihiro, Iwama, Shintaro, Banno, Ryoichi, Matsumoto, Mami, Kawakami, Natsuko, Ohno, Nobuhiko, Sakamoto, Hirotaka, Arima, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578753/
https://ncbi.nlm.nih.gov/pubmed/33103081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101648
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