Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Misfolded or unfolded proteins in the ER are said to be degraded only after translocation or isolation from the ER. Here, we describe a mechanism by which mutant proteins are degraded within the ER. Aggregates of mutant arginine vasopressin (AVP) precursor were confined to ER-associated compartments...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:iScience
Prif Awduron: Miyata, Takashi, Hagiwara, Daisuke, Hodai, Yuichi, Miwata, Tsutomu, Kawaguchi, Yohei, Kurimoto, Junki, Ozaki, Hajime, Mitsumoto, Kazuki, Takagi, Hiroshi, Suga, Hidetaka, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Ito, Yoshihiro, Iwama, Shintaro, Banno, Ryoichi, Matsumoto, Mami, Kawakami, Natsuko, Ohno, Nobuhiko, Sakamoto, Hirotaka, Arima, Hiroshi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7578753/
https://ncbi.nlm.nih.gov/pubmed/33103081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101648
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