Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme consisting of an exoribonuclease (ExoN) domain and a methyltransferase (MTase) domain and plays a pivotal role in viral replicat...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Lin, Sheng, Chen, Hua, Chen, Zimin, Yang, Fanli, Ye, Fei, Zheng, Yue, Yang, Jing, Lin, Xi, Sun, Honglu, Wang, Lingling, Wen, Ao, Dong, Haohao, Xiao, Qingjie, Deng, Dong, Cao, Yu, Lu, Guangwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136770/
https://ncbi.nlm.nih.gov/pubmed/33956156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab320
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