Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor

Bovine herpesvirus 1 (BHV-1) has received increasing attention for its potential oncolytic applications. BHV-1 recognizes nectin-1 for cell entry via viral glycoprotein D (gD) but represents a low-affinity nectin-1 binding virus. The molecular basis underlying this low receptor-binding affinity, how...

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Vydáno v:Sci Adv
Hlavní autoři: Yue, Dan, Chen, Zhujun, Yang, Fanli, Ye, Fei, Lin, Sheng, He, Bin, Cheng, Yanwei, Wang, Jichao, Chen, Zimin, Lin, Xi, Yang, Jing, Chen, Hua, Zhang, Zhonglin, You, Yu, Sun, Honglu, Wen, Ao, Wang, Lingling, Zheng, Yue, Cao, Yu, Li, Yuhua, Lu, Guangwen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220272/
https://ncbi.nlm.nih.gov/pubmed/32426511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba5147
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