Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spindle Instability

Aneuploidy originating during meiosis in oocytes is the major cause of reduced fertility, implantation failure and miscarriage in women beyond their mid-thirties. Loss of chromosome cohesion, and defective microtubule dynamics and spindle assembly are, in turn, the major contributors to the error-pr...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Rizzo, Marilena, Stout, Tom A. E., Cristarella, Santo, Quartuccio, Marco, Kops, Geert J. P. L., De Ruijter-Villani, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136435/
https://ncbi.nlm.nih.gov/pubmed/34026756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.657366
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