African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer

Polygenic hazard score (PHS) models are associated with age at diagnosis of prostate cancer. Our model developed in Europeans (PHS46), showed reduced performance in men with African genetic ancestry. We used a cross-validated search to identify SNPs that might improve performance in this population....

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Publicat a:Int J Cancer
Autors principals: Karunamuni, Roshan A., Huynh-Le, Minh-Phuong, Fan, Chun C., Thompson, Wesley, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth, Lophatananon, Artitaya, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Ian M., Blot, William J., Zheng, Wei, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Park, Jong Y., Lin, Hui-Yi, Bensen, Jeannette T., Fontham, Elizabeth T.H., Mohler, James L., Taylor, Jack A., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Romana, Marc, Leach, Robin J., John, Esther M., Fowke, Jay, Bush, William S., Aldrich, Melinda, Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Parent, Marie-Élise, Hu, Jennifer J., Sanderson, Maureen, Mills, Ian G., Andreassen, Ole A., Dale, Anders M., Seibert, Tyler M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135907/
https://ncbi.nlm.nih.gov/pubmed/32930425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.33282
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